A Stage II cervical cancer patient provided preoperative peripheral blood samples. The Labyrinth microfluidic platform successfully isolated 303 circulating tumor cells (CTCs), demonstrating:

Strong pan-cytokeratin (Pan-CK) and Nectin4 expression

Negative tissue factor (TF) detection

The elevated CTC count and Nectin4 positivity suggest potential suitability for Nectin4-targeted antibody-drug conjugate (ADC) therapy. This case highlights the critical value of pre-treatment CTC analysis in identifying actionable therapeutic targets.